2011年7月  北京大学化学与分子工程公司  理学学士学位

2017年12月  美国俄亥俄州立大学化学系  博士学位  （导师：仲冬平教授）

2011  Jul     B.S.     College of Chemistry and Molecular Engineering,  Peking University     Advisor: Na Li, Professor

2017  Dec     PhD     Department of Chemistry and Biochemistry,  the Ohio State University     Advisor: Dongping Zhong, Professor

2018年-2020年  美国俄亥俄州立大学化学系  博士后  （导师：仲冬平 教授）

2020年-2022年  美国普林斯顿大学化学系  博士后（导师：Gregory D. Scholes 教授）

2023年至今        FIFA World Cup 2026™  副教授 博士生导师

2018-2020     Postdoctoral Fellow,     Department of Chemistry and Biochemistry,  the Ohio State University      Advisor: Dongping Zhong, Professor

2020-2022     Postdoctoral Fellow,     Department of Chemistry,  Princeton University      Advisor: Gregory D. Scholes, Professor

2023-present  Associate Professor (Tenure-track),   School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University 

自然界中与光相关的蛋白质主要有三类：光合作用（Photosynthesis）中的蛋白复合体，光受体（Photoreceptor）和光酶（Photoenzyme）。光合作用将光能转化为化学能，为生物界提供能量来源；生物体依靠光受体感知环境中的光，以此调整自身、适应环境；光酶利用光能完成必要的催化反应。研究与光相关蛋白质的工作机理，并加以应用，可以促进人类对光能的利用和转化，对农业、环保、化工等领域都有重要意义。由于蛋白质分子是在动态、连续变化中完成生物学功能，所以需要在动力学的角度、从分子层面上阐述生物体系工作的机理。

李现鲲博士的研究结合了超快光谱分析和分子生物学，利用人工设计的蛋白质突变体（Mutant），配合超快光谱手段解析蛋白质动力学。李现鲲博士还致力于开发新的人工光酶，用于新的催化反应。

Ultrafast Dynamics, Femtochemistry, Reaction mechanism, Photoenzymatic catalysis

We apply time-resolved spectroscopy to investigate reaction dynamics and mechanism. We mainly focus on photoreceptors and photoenzymes.

Zhang, X.; Sun, Y.; Wang, L.; Li, X.*; Zhong, D.* Ultrafast Dynamics of Photoinduced Electron Transfer and Decarboxylation in the Flavoenzyme Lactate Monooxygenase. The Journal of Physical Chemistry B 2025, 129 (31), 7905–7911. DOI: 10.1021/acs.jpcb.5c03445.

Li, X.; Page, C. G.; Zanetti-Polzi, L.; Kalra, A. P.; Oblinsky, D. G.; Daidone, I.; Hyster, T. K.; Scholes, G. D. Mechanism and Dynamics of Photodecarboxylation Catalyzed by Lactate Monooxygenase. Journal of the American Chemical Society 2023, 145 (24), 13232-13240.

Wu, R.; Li, X.; Wang, L.; Zhong, D. Ultrafast Dynamics and Catalytic Mechanism of Fatty Acid Photodecarboxylase. Angewandte Chemie International Edition 2022, e202209180.

Li, X.; Liu, Z.; Ren, H.; Kundu, M.; Zhong, F. W.; Wang, L.; Gao, J.; Zhong, D. Dynamics and mechanism of dimer dissociation of photoreceptor UVR8. Nature communications 2022, 13 (1), 93.

Wang, D.; Qin, Y.; Zhang, M.; Li, X.; Wang, L.; Yang, X.; Zhong, D. The origin of ultrafast multiphasic dynamics in photoisomerization of bacteriophytochrome. The journal of physical chemistry letters 2020, 11 (15), 5913-5919.

Wang, D.; Li, X.; Zhang, S.; Wang, L.; Yang, X.; Zhong, D. Revealing the origin of multiphasic dynamic behaviors in cyanobacteriochrome. Proceedings of the National Academy of Sciences 2020, 117 (33), 19731-19736.

Wang, D.; Li, X.; Wang, L.; Yang, X.; Zhong, D. Elucidating ultrafast multiphasic dynamics in the photoisomerization of cyanobacteriochrome. The journal of physical chemistry letters 2020, 11 (20), 8819-8824.

Li, X.; Ren, H.; Kundu, M.; Liu, Z.; Zhong, F. W.; Wang, L.; Gao, J.; Zhong, D. A leap in quantum efficiency through light harvesting in photoreceptor UVR8. Nature communications 2020, 11 (1), 4316.

Li, X.; Liu, Z.; Ren, H.; Kundu, M.; Wang, L.; Gao, J.; Zhong, D. Dynamics and mechanism of light harvesting in UV photoreceptor UVR8. Chemical Science 2020, 11 (46), 12553-12569.

Liu, Z.; Li, X.; Zhong, F. W.; Li, J.; Wang, L.; Shi, Y.; Zhong, D. Quenching dynamics of ultraviolet-light perception by UVR8 photoreceptor. The journal of physical chemistry letters 2014, 5 (1), 69-72.

Physical Chemistry (2),  CHEM3404

2022年国家高层次人才引进计划

2022年上海市高层次人才引进计划

2022 Excellent Young Scientist Fund (Overseas), National Natural Science Foundation of China

2022 Shanghai Magnolia Talent Plan — Young Scholar Program